Oral Appliances Are Equally Effective to CPAP according to a New Study in Respiration. This Game Changing Study Is Good News For Patients Who Do Not Tolerate Or Want CPAP Masks, Hoses or Machines.

    GURNEE, IL, November 22, 2010 /24-7PressRelease/ -- Sleep Apnea treatment will dramatically change in the future. Nasal CPAP has always been the "Gold Standard" of treatment even though the majority of patients could not tolerate treatment and as many as 60% discontinue treatment. The field of Dental Sleep Medicine has been brought front and center by the website http://www.ihatecpap.com. Thousands of patients have learned about oral appliance therapy and are currently receiving treatment as a direct result of I HATE CPAP.com.

This new study may have immediate adverse effects on the stock prices of CPAP companies that are already feeling pressure from new Medicare rules that demand significant patient compliance to qualify nasal CPAP for reimbursement. It will lead to better treatment of patients who almost always prefer oral appliances to CPAP when offered a choice. Unfortunately most patients have not historically been offered oral appliance treatment. An excellent case to that point is that sleep apnea has been listed as the cause of death for a prominent Pennsylvania State Representative. Robert C. Donatucci died in his sleep on Tuesday, just one week after he won the election for his 16th House term. He refused CPAP treatment according to his brother.

Another recent article showed that CPAP causes orthopedic and orthodontic changes in patients after two years of use. The following is reprinted from Wikipedia "The CPAP mask can act as an orthodontic headgear and move the teeth and the upper and/or lower jaw backward. This effect can increase over time and may or may not cause TMD disorders in some patients. These facial changes have been dubbed "Smashed Face Syndrome". Chest. 2010 Oct;138(4):870-4. Epub 2010 Jul 8. Craniofacial changes after 2 years of nasal continuous positive airway pressure use in patients with obstructive sleep apnea. Tsuda H, Almeida FR, Tsuda T, Moritsuchi Y, Lowe AA."

Dr Ira L Shapira is a Chcago Area Dentist who created the I HATE CPAP! website and has been treating sleep apnea with Oral Appliances for over 25 years. He is a Diplomate of the American Board of Dental Sleep Medicine and a pioneer in the field of Dental Sleep Medicine. He was one of 20 dentists from around the United States at the first meeting of the Sleep Disorder Dental Society (SDDS) 19 years ago. The SDDS evolved into the American Academy of Dental Sleep Medicine. Dr Shapira did research as a visiting assistant professor at Rush Medical School's Sleep Service in the 1980's where he measured jaw position in sleep apnea patients and found distict similarities to jaw position of TMJ disorder patients. The National Heart Lung and Blood Institute (NHLBI) of the National Institute of Health (NIH) published a report on TMJ disorders and sleep apnea titled "CARDIOVASCULAR AND SLEEP-RELATED CONSEQUENCES OF TEMPOROMANDIBULAR DISORDERS"

The power of CPAP companies in the field of sleep medicine is evidenced by the fact that I HATE CPAP LLC was banned from presenting or having a booth at the American Academy of Dental Sleep Medicine meetings. The website www.ihatecpap.com is recognized as a leading source of information on Dental Sleep Medicine and Oral Appliance Therapy.

A recent article " Appliance Therapy versus Nasal Continuous Positive Airway Pressure in Obstructive Sleep Apnea: A Randomized, Placebo-Controlled Trial" in Respiration compared oral appliance therapy and nasal CPAP therapy in treating mild to moderate sleep apnea. The article looked at carefully controlled studies in which both the CPAP and the oral appliances were carefully titrated. The article concluded that "There is no clinically relevant difference between MAD and nCPAP in the treatment of mild/moderate OSA when both treatment modalities are titrated objectively."

It is important to note that the article clearly states that treatment is equal when there is objective titration of the oral appliances. I have strongly been recommending titration on all oral appliance therapy for over ten years. This is trtuly a landmark study because while CPAP has always been considered "the gold standard for treatment of sleep apnea" that statement is no longer true for mild to moderate sleep apnea.

This study did not cover severe sleep apnea therefore CPAP is still considered the gold standard of treatment for severe sleep apnea and oral appliances are an alternative for patients who do not tolerate CPAP.

The major problem with CPAP has always been low compliance. A recent study showed 60% of patients do not tolerate CPAP treatment. If compliance is factored in then it is clear that oral appliances are now the "Gold Standard" of treatment for mild to moderate sleep apnea.

PubMed abstract:
Respiration. 2010 Oct 20. [Epub ahead of print]ral Appliance Therapy versus Nasal Continuous Positive Airway Pressure in Obstructive Sleep Apnea: A Randomized, Placebo-Controlled Trial.
Aarab G, Lobbezoo F, Hamburger HL, Naeije M.

Department of Oral Kinesiology, Academic Center for Dentistry Amsterdam, Research Institute MOVE, University of Amsterdam and VU University Amsterdam, The Netherlands.
Abstract
Background: Previous randomized controlled trials have addressed the efficacy of mandibular advancement devices (MADs) in the treatment of obstructive sleep apnea (OSA). Their common control condition, nasal continuous positive airway pressure (nCPAP), was frequently found to be superior to MAD therapy. However, in most of these studies, only nCPAP was titrated objectively but not MAD. To enable an unbiased comparison between both treatment modalities, the MAD should be titrated objectively as well. Objective: The aim of the present study was to compare the treatment effects of a titrated MAD with those of nCPAP and an intra-oral placebo device. Methods: Sixty-four mild/moderate patients with obstructive sleep apnea (OSA; 52.0 +- 9.6 years) were randomly assigned to three parallel groups: MAD, nCPAP and placebo device. From all patients, two polysomnographic recordings were obtained at the hospital: one before treatment and one after approximately 6 months of treatment. Results: The change in the apnea-hypopnea index (AHI) between baseline and therapy evaluation differed significantly between the three therapy groups (ANCOVA; p = 0.000). No differences in the AHI were found between the MAD and nCPAP therapy (p = 0.092), whereas the changes in AHI in these groups were significantly larger than those in the placebo group (p = 0.000 and 0.002, respectively). Conclusion: There is no clinically relevant difference between MAD and nCPAP in the treatment of mild/moderate OSA when both treatment modalities are titrated objectively.

Copyright 2010 S. Karger AG, Basel.
PMID: 20962502 [PubMed - as supplied by publisher]

Dr Ira L Shapira is an author and section editor of Sleep and Health Journal, President of I HATE CPAP LLC, President Dato-TECH, and has a Dental Practice with his partner Dr Mark Amidei. He has recently formed Chicagoland Dental Sleep Medicine Associates. He is a Regent of ICCMO and its representative to the TMD Alliance, He was a founding and certified member of the Sleep Disorder Dental Society which became the American Academy of Dental Sleep Medicine, A founding member of DOSA the Dental Organization for Sleep Apnea. He is a Diplomate of the American Board of Dental Sleep Medicine, A Diplomat of the American Academy of Pain Management, a graduate of LVI. He is a former assistant professor at Rush Medical School's Sleep Service where he worked with Dr Rosalind Cartwright who is a founder of Sleep Medicine and Dental Sleep Medicine. Dr Shapira is a consultant to numerous sleep centers and teaches courses in Dental Sleep Medicine in his office to doctors from around the U.S. He is the Founder of I HATE CPAP LLC and http://www.ihatecpap.com Dr Shapira also holds several patents on methods and devices for the prophylactic minimally invasive early removal of wisdom teeth and collection of bone marrow and stem cells. Dr Shapira is a licensed general dentist in Illinois and Wisconsin.

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